Both genetic pre-disposition and potential environmental triggers are shared between Rheumatoid arthritis (RA) and Crohn’s disease (CD). The authors hypothesised that single nucleotide polymorphisms (SNPs) in the negative T-cell regulators Protein Tyrosine Phosphatase Nonreceptor type 2 and 22 (PTPN2/22) lead to the dysregulated immune response as seen in RA and CD.
This is the first study to report the correlation between SNPs in PTPN2/22, IFN-y expression and MAP in autoimmune disease.